Gregory Sonnenberg Lab

Inflamed Mouse Colon (Pink)

Color-enhanced histologic image of a severely inflamed mouse colon following a T cell transfer model of colitis, demonstrating crypt elongation, loss of normal architecture and inflammatory cell infiltrates.

Immune system and Intestinal barrier

This color-enhanced microscopic image of a mouse intestine demonstrates the presence of the immune system and intestinal barrier.
Image credit: Drs. Mario Noti, Matthew R. Hepworth and Gregory F. Sonnenberg

Commensal bacteria and immune cells

Microscopic image of a unique type of commensal bacteria (depicted in yellow and green) residing in close contact with immune cells (depicted in blue) outside of the intestine in mice. The bacteria appear to protect the mice from inflammation and illness. Image Credit: Dr. Greg Sonnenberg & Thomas Fung.

The intestinal barrier

The intestinal barrier. Color-enhanced image of the intestinal lining, which serves as a barrier and limits dissemination of the microbiota. Image credit: Drs. Greg Sonnenberg and David Artis, Weill Cornell Medicine.

Murine mesenteric lymph node (yellow)

Interfollicular area of a murine mesenteric lymph node demonstrating the presence of RORgt+ILC3. RORgt (purple), IL-7Ra (cyan), and B220 (yellow).

Lymphoid Follicle (blue)

Lymphoid Follicle in the colon of a healthy mouse demonstrating the presence of RORgt+ILC3. The section is stained for RORgt (green), IL-7Ra (red) and CD3 (blue).

About Us

The Sonnenberg Laboratory is composed of a diverse group of postdoctoral researchers, students, and technicians working to elucidate the mechanisms by which the mammalian immune system controls tissue homeostasis, immunity, inflammation and cancer. Our focus is to define novel pathways contributing to chronic diseases and develop novel preventative, therapeutic and curative strategies. The Sonnenberg Laboratory has published our major findings in journals such as Nature, Science, Nature Medicine and Immunity. As part of the Jill Roberts Institute for Research in Inflammatory Bowel Disease, the Sonnenberg Lab has a particular focus on investigating the role of the gut microbiome and mammalian immune system in intestinal health and disease.

Talented graduate students and postdoctoral researchers are encouraged to directly contact Dr. Sonnenberg to discuss potential rotation projects and open positions in the laboratory.