Submitted by nuz4001 on April 27, 2026 - 11:20am
| Title | Diet-induced death: microbiome-mediated lipid stress reduces intestinal ILC3s. |
| Publication Type | Journal Article |
| Year of Publication | 2026 |
| Authors | Kim MJoon, Sonnenberg GF |
| Journal | Trends Immunol |
| Volume | 47 |
| Issue | 4 |
| Pagination | 252-254 |
| Date Published | 2026 Apr |
| ISSN | 1471-4981 |
| Keywords | Animals, Diet, Diet, High-Fat, Gastrointestinal Microbiome, Humans, Immunity, Innate, Inflammation, Intestinal Mucosa, Intestines, Lipid Metabolism, Lymphocytes, Mice |
| Abstract | Group 3 innate lymphoid cells (ILC3s) promote gastrointestinal health, dynamically interface with diet and microbes, and become impaired during chronic inflammation or metabolic syndrome. Torrico and colleagues uncover a key pathway rapidly disrupting ILC3 homeostasis in the intestines of humans and mice following the consumption of a high-fat diet. |
| DOI | 10.1016/j.it.2026.03.002 |
| Alternate Journal | Trends Immunol |
| PubMed ID | 41887976 |